Little empirically-based information is availableregarding how best to intervene with substance-abusing homeless mothers.This study pilot-tested a comprehensive intervention with 15 homelesswomen and their 2- to 6-year-old children, recruited from a local familyshelter. All participants were offered integrated intervention withthree major components. The first component was housing which included 3months of rental and utility assistance, and these services were notcontingent upon women's abstinence from drugs or alcohol. The second andthird components included 6 months of case management services and anevidence-based substance abuse treatment (Community ReinforcementApproach; CRA). Analysis revealed that women showed reductions insubstance use (F _2,22 = 3.63; p < .05), homelessness (F _2,24 = 25.31; p < .001), and mental health problems (F _2,20 = 8.5; p < .01). Further, women reported reduced internalizing (F _2,22 = 4.08; p < .05) and externalizing problems (F _2,24 = 7.7; p= .01) among their children. The findings suggest that the interventionis a promising approach to meet the multiple needs of this vulnerablepopulation. These positive outcomes support the need for future researchto replicate the findings with a larger sample using a randomizeddesign. (Authors)